Limits of early diagnosis of herpes simplex encephalitis in children:: A retrospective study of 38 cases

被引：55

作者：

De Tiège, X

Héron, B

Lebon, P

Ponsot, R

Rozenberg, F

机构：

[1] Hop St Vincent de Paul, Virol Lab, F-75674 Paris 14, France

[2] Free Univ Brussels, TEP, Biomed Cyclotron Unit, Hop Erasme, Brussels, Belgium

来源：

CLINICAL INFECTIOUS DISEASES | 2003年 / 36卷 / 10期

关键词：

D O I：

10.1086/374839

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prognosis of herpes simplex encephalitis (HSE) depends on the early and appropriate administration of specific antiviral therapy. We retrospectively reviewed 38 cases of children with proven HSE, to evaluate the reliability of polymerase chain reaction results, according to the time of cerebrospinal fluid (CSF) sampling. Initial negative results were observed in 8 of 33 CSF samples drawn before day 3 of the disease and were significantly associated with a low level of protein and <10 leukocytes/mm(3) in the CSF.

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收藏

页码：1335 / 1339

页数：5

相关论文

共 24 条

[1] HSVPCR for CNS infections: Pearls and pitfalls [J].

Atkins, JT .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1999, 18 (09) :823-824

[2] DEMONSTRATION OF HERPES-SIMPLEX VIRUS-DNA IN CSF CELLS BY INSITU HYBRIDIZATION FOR EARLY DIAGNOSIS OF HERPES-ENCEPHALITIS [J].

BAMBORSCHKE, S ;

PORR, A ;

HUBER, M ;

HEISS, WD .

JOURNAL OF NEUROLOGY, 1990, 237 (02) :73-76

[3] RELAPSE OF HERPES-SIMPLEX ENCEPHALITIS [J].

BARTHEZCARPENTIER, MA ;

ROZENBERG, F ;

DUSSAIX, E ;

LEBON, P ;

GOUDEAU, A ;

BILLARD, C ;

TARDIEU, M .

JOURNAL OF CHILD NEUROLOGY, 1995, 10 (05) :363-367

[4] SPREAD OF HERPES-SIMPLEX VIRUS TO THE CEREBROSPINAL-FLUID AND THE MENINGES IN EXPERIMENTAL MOUSE ENCEPHALITIS [J].

BOERMAN, RH ;

PETERS, ACB ;

BLOEM, BR ;

RAAP, AK ;

VANDERPLOEG, M .

ACTA NEUROPATHOLOGICA, 1992, 83 (03) :300-307

[5] A 6-year-old child with vacant episodes and unilateral convulsions [J].

Burgner, D ;

McDonald, D ;

Watson, M ;

Pike, M .

LANCET, 1998, 352 (9142) :1750-1750

[6] The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: A consensus report [J].

Cinque, P ;

Cleator, GM ;

Weber, T ;

Monteyne, P ;

Sindic, CJ ;

vanLoon, AM .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1996, 61 (04) :339-345

[7] Evaluation of the range of clinical presentations of herpes simplex encephalitis by using polymerase chain reaction assay of cerebrospinal fluid samples [J].

Domingues, RB ;

Tsanaclis, AMC ;

Pannuti, CS ;

Mayo, MS ;

Lakeman, FD .

CLINICAL INFECTIOUS DISEASES, 1997, 25 (01) :86-91

[8] Advantage of polymerase chain reaction in the diagnosis of herpes simplex encephalitis: Presentation of 5 atypical cases [J].

Domingues, RB ;

Lakeman, FD ;

Pannuti, CS ;

Fink, MCD ;

Tsanaclis, AMC .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1997, 29 (03) :229-231

[9] SIGNIFICANCE AND CLINICAL RELEVANCE OF THE DETECTION OF HERPES-SIMPLEX VIRUS-DNA BY THE POLYMERASE CHAIN-REACTION IN CEREBROSPINAL-FLUID FROM PATIENTS WITH PRESUMED ENCEPHALITIS [J].

GUFFOND, T ;

DEWILDE, A ;

LOBERT, PE ;

LEFEBVRE, DC ;

HOBER, D ;

WATTRE, P .

CLINICAL INFECTIOUS DISEASES, 1994, 18 (05) :744-749

[10] Diagnosis of viral infections of the central nervous system: Clinical interpretation of PCR results [J].

Jeffery, KJM ;

Read, SJ ;

Peto, TEA ;

MayonWhite, RT ;

Bangham, CRM .

LANCET, 1997, 349 (9048) :313-317