A phase III trial of efficacy of the FML-vaccine against canine kala-azar in an endemic area of Brazil (Sao Goncalo do Amaranto, RN)

被引：95

作者：

da Silva, VO

Borja-Cabrera, GP

Pontes, NNC

de Souza, EP

Luz, KG

Palatnik, M

de Sousa, CBP

机构：

[1] Univ Fed Rio de Janeiro, CCS, Inst Microbiol, Ilha Fundao, BR-21941590 Rio De Janeiro, Brazil

[2] Univ Fed Rio Grande do Norte, Fac Med, BR-59072970 Natal, RN, Brazil

[3] Hosp Univ Clementino Fraga Filho, Fac Med, Rio De Janeiro, Brazil

来源：

VACCINE | 2000年 / 19卷 / 9-10期

关键词：

canine visceral leishmaniasis; zoonoses; kala-azar; Leishmania donovani;

D O I：

10.1016/S0264-410X(00)00339-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protection against canine kala-azar was investigated in naturally exposed dogs of an endemic area, vaccinated with the fucose mannose ligand (FML)-vaccine of Leishmania donovani. A total of 97% of vaccinees were seropositive to FML and 100% showed intradermal reaction to L. donovani lysate, 7 months after vaccination. The absorbency values and size of intradermal reaction were both significantly higher in vaccinees than in controls (ANOVA, P < 0.0001). After 2 years, 92% (<chi>(2) = 6.996; P < 0.0025) protection was achieved: only 8% of vaccinees showed mild signs of kala-azar with no deaths while 33% of controls developed clinical or fatal disease. The FML-vaccine induced a significant, long-lasting and strong protective effect against canine kala-azar in the field. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1082 / 1092

页数：11

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