t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes:: characterization of a new subset of T acute lymphoblastic leukaemia

被引：28

作者：

Mecucci, C

La Starza, R

Negrini, M

Sabbioni, S

Crescenzi, B

Leoni, P

Di Raimondo, F

Krampera, M

Cimino, G

Tafuri, A

Cuneo, A

Vitale, A

Foà, R

机构：

[1] Univ Perugia, Dipartimento Med Clin & Sperimentale, I-06100 Perugia, Italy

[2] Univ Ferrara, Dipartimento Med Sperimentale & Diagnost, I-44100 Ferrara, Italy

[3] Univ Ancona, Chair Haematol, Ancona, Italy

[4] Univ Catania, Chair Haematol, Catania, Italy

[5] Univ Verona, Dipartimento Med Clin & Sperimentale, I-37100 Verona, Italy

[6] Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, Rome, Italy

[7] Univ Ferrara, Dipartimento Sci Biomed & Terapie Avanzate, I-44100 Ferrara, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2000年 / 109卷 / 04期

关键词：

t(4; 11)(q21; p15); NUP98-RAP1GDS1; T-ALL;

D O I：

10.1046/j.1365-2141.2000.02106.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Two cases of T acute lymphoblastic leukaemia (T-ALL) with an identical t(4;11)(q21;p15) translocation were identified within a prospective study on the biological and clinical features of adult ALL patients enrolled into the therapeutic protocol ALL0496 of the GIMEMA Italian Group. In both cases, the molecular characterization showed an involvement of the NUP98 gene on 11p15 which rearranges with the RAP1GDS1 gene on 4q21. The morphological and immunological features of the leukaemic cells, as well as the clinical behaviour and response to induction therapy, were the same in both patients. Based on the available data, the t(4;11)(q21;p15) translocation involving the NUP98-RAP1GDS1 fusion gene emerges as a new highly specific genetic abnormality that characterizes a subset of T-ALL.

引用

页码：788 / 793

页数：6

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