A Direct, Copper-Catalyzed Functionalization of Pyridines with Alkynes

被引：22

作者：

Beveridge, Ramsay E. ^{[1
,2
]}

Arndtsen, Bruce A. ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

[2] Pfizer Global Res & Dev, Groton, CT 06340 USA

来源：

SYNTHESIS-STUTTGART | 2010年 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

pyridine; copper; catalytic; alkyne; alkene; CROSS-COUPLING REACTIONS; 1-ACYLPYRIDINIUM SALTS; N-OXIDES; STEREOSELECTIVE-SYNTHESIS; MULTICOMPONENT SYNTHESIS; REGIOSELECTIVE ADDITION; EFFICIENT SYNTHESIS; DIRECT ARYLATION; ACID-CHLORIDES; ONE-STEP;

D O I：

10.1055/s-0029-1218632

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot, copper-catalyzed method to construct 2-alkynylpyridines is presented. This provides a route to access these products directly from terminal alkynes and the parent pyridine, and without prefunctionalization of the pyridine core. In addition, (Z)-alk-2-enylpyridines can be prepared via a related procedure. These reactions are used to synthesize a number of new alkynyl- and alkenyl-substituted pyridines in one pot.

引用

页码：1000 / 1008

页数：9

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