Higher cortisol awakening response in young adolescents with persistent anxiety problems

被引：107

作者：

Greaves-Lord, K.

Ferdinand, R. F.

Oldehinkel, A. J.

Sondeijker, F. E. P. L.

Ormel, J.

Verhulst, F. C.

机构：

[1] Sophia Childrens Univ Hosp, Dept Child & Adolescent Psychiat, Erasmus Med Ctr, NL-3015 GJ Rotterdam, Netherlands

[2] Univ Groningen, Dept Psychiat, Groningen, Netherlands

[3] Univ Groningen, Grad Sch Behav & Cognit Neurosci, Groningen, Netherlands

[4] Grad Sch Expt Psychopathol, Grad Sch, Groningen, Netherlands

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2007年 / 116卷 / 02期

关键词：

Hypothalamo-Hypophyseal System (HPA-axis); anxiety; adolescent; population;

D O I：

10.1111/j.1600-0447.2007.01001.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The aims of the present study were to test the association between current anxiety problems and basal cortisol levels in a large population sample of young preadolescents, and to test if HPA-axis activity differs between individuals with no, only current, or persistent anxiety problems. Method: Cortisol levels of 10- to 12-year olds (n = 1768) from the general population were measured on three time points during the day. A self-report questionnaire (RCADS) was used to assess current anxiety, a parent-report questionnaire (TPBQ) to assess anxiety problems at age 4. Results: Associations between cortisol levels and current anxiety problems were not found. However, individuals with persistent anxiety problems had higher morning cortisol levels and a higher cortisol awakening response. Conclusion: Apparently, only persistent, and not current, anxiety problems are associated with higher HPA-axis activity. Alterations in HPA-axis activity might underlie persistent anxiety problems, or result from the stress accompanied by persistent anxiety problems.

引用

页码：137 / 144

页数：8

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