Role of interleukin-10 in the induction and function of natural and antigen-induced regulatory T cells

被引:18
作者
Wraith, DC [1 ]
机构
[1] Univ Bristol, Sch Med Sci, Dept Pathol & Microbiol, Bristol BS8 1TD, Avon, England
关键词
autoimmune; interleukin-10; regulation; T cell; tolerance;
D O I
10.1016/S0896-8411(03)00046-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:273 / 275
页数:3
相关论文
共 26 条
[1]   Mechanisms of interleukin-10-mediated immune suppression [J].
Akdis, CA ;
Blaser, K .
IMMUNOLOGY, 2001, 103 (02) :131-136
[2]   Mechanisms of central and peripehral T-cell tolerance: lessons from experimental models of multiple sclerosis [J].
Anderton, S ;
Burkhart, C ;
Metzler, B ;
Wraith, D .
IMMUNOLOGICAL REVIEWS, 1999, 169 :123-137
[3]   An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation [J].
Asseman, C ;
Mauze, S ;
Leach, MW ;
Coffman, RL ;
Powrie, F .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (07) :995-1003
[4]   In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines [J].
Barrat, FJ ;
Cua, DJ ;
Boonstra, A ;
Richards, DF ;
Crain, C ;
Savelkoul, HF ;
de Waal-Malefyt, R ;
Coffman, RL ;
Hawrylowicz, CM ;
O'Garra, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :603-616
[5]   CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity [J].
Belkaid, Y ;
Piccirillo, CA ;
Mendez, S ;
Shevach, EM ;
Sacks, DL .
NATURE, 2002, 420 (6915) :502-507
[6]   Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo [J].
Buer, J ;
Lanoue, A ;
Franzke, A ;
Garcia, C ;
von Boehmer, H ;
Sarukhan, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (02) :177-183
[7]   Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10 [J].
Burkhart, C ;
Liu, GY ;
Anderton, SM ;
Metzler, B ;
Wraith, DC .
INTERNATIONAL IMMUNOLOGY, 1999, 11 (10) :1625-1634
[8]   Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood [J].
Dieckmann, D ;
Plottner, H ;
Berchtold, S ;
Berger, T ;
Schuler, G .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (11) :1303-1310
[9]   Interleukin-10 induces a long-term antigen-specific anergic state in human CD4(+) T cells [J].
Groux, H ;
Bigler, M ;
deVries, JE ;
Roncarolo, MG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (01) :19-29
[10]   IL-2 unresponsiveness in anergic CD4+ T cells is due to defective signaling through the common γ-chain of the IL-2 receptor [J].
Grundström, S ;
Dohlsten, M ;
Sundstedt, A .
JOURNAL OF IMMUNOLOGY, 2000, 164 (03) :1175-1184