Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy

被引：46

作者：

Dewhirst, Mark W. ^{[1
]}

Cao, Yiting

Li, Chuan Yuan

Moeller, Benjamin

机构：

[1] Duke Univ, Med Ctr, Durham, NC 27710 USA

[2] Univ Colorado, Hlth Sci Ctr, Denver, CO USA

[3] MD Anderson Canc Ctr, Houston, TX USA

来源：

RADIOTHERAPY AND ONCOLOGY | 2007年 / 83卷 / 03期

关键词：

hypoxia; HIF-1; angiogenesis; radiotherapy response;

D O I：

10.1016/j.radonc.2007.05.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The objective of this review is to examine the role that HIF-1 plays in the initiation of angiogenesis and in radiotherapy response. Although these two phenomena may at first seem unrelated, there are parallelisms to be drawn associated with the importance of reactive oxygen species in controlling the transcriptional activity of HIF-1, independently of its main driving force, hypoxia. Knowledge of the mechanisms underlying the control of HIF-1 leads to rationale for its inhibition in a range of clinical scenarios. (C) 2007 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 83 (2007) 249-255.

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页码：249 / 255

页数：7

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