TNF-α and insulin resistance:: Summary and future prospects

被引：226

作者：

Peraldi, P ^{[1
]}

Spiegelman, B ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1998年 / 182卷 / 1-2期

关键词：

insulin resistance; TNF-alpha; obesity; insulin signaling; adipocyte; IRS-1;

D O I：

10.1023/A:1006865715292

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

While the causes of obesity remain elusive, the relationship between obesity and insulin resistance is a well-established fact [1]. Insulin resistance is defined as a smaller than normal response to a certain dose of insulin, and contributes to several pathological problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension. Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-alpha) is an important player in the state of insulin resistance observed during obesity. In this review we will try to summarize what is known about the function of TNF-alpha in insulin resistance during obesity and how TNF-alpha interferes with insulin signaling.

引用

页码：169 / 175

页数：7

共 58 条

[1] FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase [J].