Effect of combination therapy with aminoglutethimide and hydrocortisone on prostate-specific antigen response in metastatic prostate cancer refractory to standard endocrine therapy

被引:24
作者
Kruit, WHJ [1 ]
Stoter, G [1 ]
Klijn, JGM [1 ]
机构
[1] Dr Daniel Den Hoed Canc Ctr, Erasmus Med Ctr, Dept Med Oncol, NL-3008 AE Rotterdam, Netherlands
关键词
aminoglutethimide; androgen independent prostate cancer; prostate-specific antigen;
D O I
10.1097/00001813-200410000-00004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response. Thirty-five patients were treated with aminoglutethimide 1000 mg daily and hydrocortisone acetate 40 mg daily. PSA measurements were performed every month. If evaluable lesions were present, objective tumor assessment was done by computed tomography scan and X-ray investigations. In 12 patients (37%) the PSA value showed a confirmed response with a decline in serum level of at least 50%. Median time to progression in responding and all patients was 10.5 and 4.5 months, respectively. Median duration of response in responding patients was 9 months. Median survival for these two groups was 23 and 14.5 months, respectively. Of seven patients with measurable disease, two showed a partial response and five a stable disease. Improvement in general condition, pain and feeling of well-being was noted in two-thirds of patients. Therapy was well tolerated with mainly grade I and II adverse events in 20% of patients. We conclude that aminoglutethimide is a valuable second-line therapy for patients with androgen-independent prostate cancer. (C) 2004 Lippincott Williams Wilkins.
引用
收藏
页码:843 / 847
页数:5
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