Obesity, diabetes mellitus and last but not least, osteoporosis

被引：38

作者：

de Paula, Francisco J. A. ^{[1
,2
]}

Rosen, Clifford J. ^{[1
]}

机构：

[1] Maine Med Ctr, Res Inst, Scarborough, ME 04074 USA

[2] Univ Sao Paulo, FMRP, Dept Med Interna, Ribeirao Preto, SP, Brazil

来源：

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2010年 / 54卷 / 02期

关键词：

Osteoporosis; obesity; diabetes mellitus; bariatric surgery; thiazolidinediones; BONE-MINERAL DENSITY; WEIGHT-LOSS; POSTMENOPAUSAL WOMEN; BARIATRIC SURGERY; HIP FRACTURE; HIGH GLUCOSE; BODY-WEIGHT; FAT MASS; REDUCTION; TURNOVER;

D O I：

10.1590/S0004-27302010000200010

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Knowledge about the influence of bone on intermediary metabolism corresponds to a developing area that has gained prominence. The old concept of bone and adipose tissues as inert metabolic tissues, with minor contributions to metabolic adaptations has been reconsidered in light of findings that bone is involved in the development of insulin sensitivity. Similarly adipose tissue exerts important influences on bone mass development and maintenance. Moreover, the use of drugs in the treatment of metabolic disorders such as diabetes mellitus can impact bone metabolism. These networks linking osteoporosis to obesity and diabetes mellitus have reinvigorated investigations in the pathophysiology of osteoporosis. The present review examines this aspect and calls attention to health care providers and potential treatments of skeletal disorder. Arq Bras Endocrinol Metab 2010;54(2):150-7

引用

页码：150 / 157

页数：8

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