Organocatalytic enantioselective aziridination of α,β-unsaturated aldehydes

被引：193

作者：

Vesely, Jan ^{[1
]}

Ibrahem, Ismail ^{[1
]}

Zhao, Gui-Ling ^{[1
]}

Rios, Ramon ^{[1
]}

Cordova, Armando ^{[1
]}

机构：

[1] Univ Stockholm, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 05期

关键词：

D O I：

10.1002/anie.200603810

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Simple chiral amines catalyze a highly chemo- and enantioselective aziridination of α,β-unsaturated aldehydes to provide 2-formylaziridines in good yields and with up to 99% ee. The synthetic utility of this organocatalytic method was exemplified in a two-step asymmetric synthesis of β-amino acid esters with readily removable protecting groups (see scheme; R1 = tert-butoxycarbonyl, benzyloxycarbonyl). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：778 / 781

页数：4

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