Bronchodilator reversibility in chronic obstructive pulmonary disease: use and limitations

被引:83
作者
Calverley, Peter M. A. [1 ,2 ]
Albert, Paul [2 ]
Walker, Paul P. [2 ]
机构
[1] Univ Liverpool, Sch Ageing & Chron Dis, Liverpool L69 3BX, Merseyside, England
[2] Aintree Univ Hosp NHS Fdn Trust, Aintree Chest Ctr, Liverpool L9 7AL, Merseyside, England
关键词
AIR-FLOW LIMITATION; MAST-CELL INFILTRATION; LATIN-AMERICAN CITIES; FLUTICASONE PROPIONATE; DYNAMIC HYPERINFLATION; EXERCISE PERFORMANCE; LUNG HEALTH; COPD; RESPONSIVENESS; SALMETEROL;
D O I
10.1016/S2213-2600(13)70086-9
中图分类号
R4 [临床医学];
学科分类号
100218 [急诊医学];
摘要
The change in forced expiratory volume in 1 s (FEV1) after administration of a short-acting bronchodilator has been widely used to identify patients with chronic obstructive pulmonary disease (COPD) who have a potentially different disease course and response to treatment. Despite the apparent simplicity of the test, it is difficult to interpret or rely on. Test performance is affected by the day of testing, the severity of baseline lung-function impairment, and the number of drugs given to test. Recent data suggest that the response to bronchodilators is not enhanced in patients with COPD and does not predict clinical outcomes. In this Review we will discuss the insight that studies of bronchodilator reversibility have provided into the nature of the COPD, and how the abnormal physiology seen in patients with this disorder can be interpreted.
引用
收藏
页码:564 / 573
页数:10
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