Articular cartilage repair - Rabbit experiments with a collagen gel-biomatrix and chondrocytes cultured in it

被引:164
作者
Kawamura, S
Wakitani, S
Kimura, T
Maeda, A
Caplan, AI
Shino, K
Ochi, T
机构
[1] Osaka Minami Natl Hosp, Dept Orthoped, Osaka 586, Japan
[2] Osaka Univ, Sch Med, Dept Orthoped, Osaka 565, Japan
[3] Case Western Reserve Univ, Dept Biol, Skeletal Res Ctr, Cleveland, OH 44106 USA
来源
ACTA ORTHOPAEDICA SCANDINAVICA | 1998年 / 69卷 / 01期
关键词
D O I
10.3109/17453679809002358
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
To repair a full-thickness articular cartilage defect in rabbit knees, we developed a technique of using a collagen gel hardened by cultured allogeneic chondrocytes in it. The gel-chondrocyte composite accumulated an intense metachromatic matrix, and had elasticity and stiffness enough to be shaped easily after 2 weeks' culture in vitro. It was implanted into full-thickness articular cartilage defects. Histologic evaluation was performed up to 6 months after surgery, using a histologic grading scale composed of 5 categories. In the gel-chondrocyte composite implanted group, good repair was observed from as early as 1 day up to 6 months, On the other hand, in the empty control group, no repair was observed 1 day to 2 weeks after the defects were made, At 4 weeks, some repair occurred, but even at 6 months the repair was not good.
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页码:56 / 62
页数:7
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