Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

被引：629

作者：

Chen, Yijing ^{[1
]}

Xu, Jinying ^{[1
,2
]}

Chen, Yu ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Shenzhen Hong Kong Inst Brain Sci Shenzhen Fundam, Key Lab Brain Connectome & Manipulat, Brain Cognit & Brain Dis Inst,Shenzhen Key Lab Tr, Shenzhen 518055, Peoples R China

[2] Univ Chinese Acad Sci, Shenzhen Coll Adv Technol, Beijing 100049, Peoples R China

[3] Shenzhen Fundamental Res Inst, HKUST Shenzhen Res Inst, Shenzhen Hong Kong Inst Brain Sci, Guangdong Prov Key Lab Brain Sci Dis & Drug Dev, Shenzhen 518057, Peoples R China

来源：

NUTRIENTS | 2021年 / 13卷 / 06期

基金：

国家重点研发计划;

关键词：

gut microbiota; neurotransmitters; cognition; neurodegeneration; Alzheimer's disease; DEPRESSIVE-LIKE BEHAVIORS; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; MYENTERIC NEURONS; FECAL MICROBIOTA; MOUSE MODEL; TRANSFER THERAPY; AUTISM SYMPTOMS; NERVOUS-SYSTEM; BRAIN AXIS;

D O I：

10.3390/nu13062099

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among the metabolic, peripheral immune, and central nervous systems via the microbiota-gut-brain axis. However, it is not well understood how the gut microbiome and neurons in the brain mutually interact or how these interactions affect normal brain functioning and cognition. We summarize the mechanisms whereby the gut microbiota regulate the production, transportation, and functioning of neurotransmitters. We also discuss how microbiome dysbiosis affects cognitive function, especially in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

引用

页数：21

共 132 条

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