Dopaminergic modulation of inhibitory glutamate receptors in the lobster stomatogastric ganglion

被引:17
作者
Cleland, TA [1 ]
Selverston, AI [1 ]
机构
[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA
关键词
D O I
10.1152/jn.1997.78.6.3450
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The intrinsic rhythmicity of the spiny lobster stomatograstric ganglion (STG) is strongly influenced by the strengths of the graded synapses between identified cells within the neural network. These synaptic strengths can be powerfully influenced by chemical neuromodulators such as dopamine and serotonin. Most of the intraganglionic chemical synapses in the STG are mediated by postsynaptic inhibitory glutamate receptors (IGluRs). To determine whether or not direct effects on these IGluRs contribute to the modulation of synaptic strength, unidentified STG neurons were extracted into primary culture and the effects of these aminergic neuromodulators on the glutamate-evoked membrane current were assessed. Dopamine (100 mu M) reliably and significantly reduced the whole cell slope conductance of all IGluRs tested. Serotonin (20 mu M) never affected the IGlu response, although it clearly altered other cellular membrane properties. Although all identified STG neurons may not conform to these observations, the data reveal a specific dopamine activated modulatory pathway within cultured neurons that reduces IGluR slope conductance. The relationship between IGluR modulation and net synaptic modulation in situ contributes to an emerging model in which synaptic strengths can be multiply modulated at different functional sites, yielding a complex, distributed, and state-dependent regulatory structure.
引用
收藏
页码:3450 / 3452
页数:3
相关论文
共 20 条
[1]  
[Anonymous], 2007, Biostatistical analysis
[2]   Functional uncoupling of linked neurotransmitter effects by combinatorial convergence [J].
Brezina, V ;
Orekhova, IV ;
Weiss, KR .
SCIENCE, 1996, 273 (5276) :806-810
[3]   REGULATION OF CELLULAR CALCIUM THROUGH SIGNALING CROSS-TALK INVOLVES AN INTRICATE INTERPLAY BETWEEN THE ACTIONS OF RECEPTORS, G-PROTEINS, AND 2ND-MESSENGERS [J].
BYGRAVE, FL ;
ROBERTS, HR .
FASEB JOURNAL, 1995, 9 (13) :1297-1303
[4]  
Cleland T. A., 1996, Society for Neuroscience Abstracts, V22, P337
[5]  
CLELAND TA, 1995, J NEUROSCI, V15, P6631
[6]   Inhibitory glutamate receptor channels [J].
Cleland, TA .
MOLECULAR NEUROBIOLOGY, 1996, 13 (02) :97-136
[7]  
EISEN JS, 1982, J NEUROPHYSIOL, V48, P1392, DOI 10.1152/jn.1982.48.6.1392
[8]   AMINERGIC MODULATION IN LOBSTER STOMATOGASTRIC GANGLION .2. TARGET NEURONS OF DOPAMINE, OCTOPAMINE, AND SEROTONIN WITHIN THE PYLORIC CIRCUIT [J].
FLAMM, RE ;
HARRISWARRICK, RM .
JOURNAL OF NEUROPHYSIOLOGY, 1986, 55 (05) :866-881
[9]   AMINERGIC MODULATION IN LOBSTER STOMATOGASTRIC GANGLION .1. EFFECTS ON MOTOR PATTERN AND ACTIVITY OF NEURONS WITHIN THE PYLORIC CIRCUIT [J].
FLAMM, RE ;
HARRISWARRICK, RM .
JOURNAL OF NEUROPHYSIOLOGY, 1986, 55 (05) :847-865
[10]  
HARRISWARRICK RM, 1995, J NEUROSCI, V15, P342