An Exclusively Human Milk-Based Diet Is Associated with a Lower Rate of Necrotizing Enterocolitis than a Diet of Human Milk and Bovine Milk-Based Products

被引：682

作者：

Sullivan, Sandra ^{[1
]}

Schanler, Richard J. ^{[2
,3
]}

Kim, Jae H. ^{[5
]}

Patel, Aloka L. ^{[8
]}

Trawoger, Rudolf ^{[15
]}

Kiechl-Kohlendorfer, Ursula ^{[15
]}

Chan, Gary M. ^{[9
]}

Blanco, Cynthia L. ^{[10
]}

Abrams, Steven ^{[11
]}

Cotten, C. Michael ^{[12
]}

Laroia, Nirupama ^{[4
]}

Ehrenkranz, Richard A. ^{[13
]}

Dudell, Golde ^{[6
]}

Cristofalo, Elizabeth A. ^{[14
]}

Meier, Paula ^{[9
]}

Lee, Martin L. ^{[7
]}

Rechtman, David J. ^{[7
]}

Lucas, Alan ^{[16
]}

机构：

[1] Univ Florida, Dept Pediat, Gainesville, FL USA

[2] Schneider Childrens Hosp N Shore, Dept Pediat, Manhasset, NY USA

[3] Albert Einstein Coll Med, Bronx, NY 10467 USA

[4] Univ Rochester, Dept Pediat, Golisano Childrens Hosp Strong, Rochester, NY USA

[5] Univ Calif San Diego, Med Ctr, Dept Pediat, San Diego, CA 92103 USA

[6] Childrens Hosp & Res Ctr, Oakland, CA USA

[7] Prolacta Biosci, Monrovia, CA USA

[8] Rush Univ, Med Ctr, Chicago, IL 60612 USA

[9] Univ Utah, Med Ctr, Dept Pediat, Salt Lake City, UT 84132 USA

[10] Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX 78229 USA

[11] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[12] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA

[13] Yale Univ, Sch Med, New Haven, CT USA

[14] Johns Hopkins Sch Med, Dept Pediat, Baltimore, MD USA

[15] Innsbruck Med Univ, Dept Pediat, Innsbruck, Austria

[16] Inst Child Hlth, MRC, Child Nutr Res Ctr, London, England

来源：

JOURNAL OF PEDIATRICS | 2010年 / 156卷 / 04期

关键词：

BIRTH-WEIGHT INFANTS; TRIAL; FORMULA;

D O I：

10.1016/j.jpeds.2009.10.040

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective To evaluate the health benefits of an exclusively human milk-based diet compared with a diet of both human milk and bovine milk-based products in extremely premature infants. Study design Infants fed their own mothers' milk were randomized to 1 of 3 study groups. Groups HM100 and HM40 received pasteurized donor human milk-based human milk fortifier when the enteral intake was 100 and 40 mL/kg/d, respectively, and both groups received pasteurized donor human milk if no mother's milk was available. Group BOV received bovine milk-based human milk fortifier when the enteral intake was 100 mL/kg/d and preterm formula if no mother's milk was available. Outcomes included duration of parenteral nutrition, morbidity, and growth. Results The 3 groups (total n = 207 infants) had similar baseline demographic variables, duration of parenteral nutrition, rates of late-onset sepsis, and growth. The groups receiving an exclusively human milk diet had significantly lower rates of necrotizing enterocolitis (NEC; P = .02) and NEC requiring surgical intervention (P = .007). Conclusions For extremely premature infants, an exclusively human milk-based diet is associated with significantly lower rates of NEC and surgical NEC when compared with a mother's milk-based diet that also includes bovine milk-based products. (J Pediatr 2010; 156: 562-7).

引用

页码：562 / U83

页数：7

共 22 条

[1] A United States national reference for fetal growth [J].