Solid-phase extraction for combinatorial libraries

被引：43

作者：

Nilsson, UJ ^{[1
]}

机构：

[1] Univ Lund, Ctr Chem & Chem Engn, SE-22100 Lund, Sweden

来源：

JOURNAL OF CHROMATOGRAPHY A | 2000年 / 885卷 / 1-2期

关键词：

review; solid-phase extraction; combinatorial chemistry; synthesis;

D O I：

10.1016/S0021-9673(99)01095-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Solid-phase extraction (SPE) has during the last three years emerged as a convenient method for the purification of compound libraries prepared by solution synthesis. The widespread use of SPE in combinatorial chemistry can be explained by straightforward SPE method development facilitated by the availability of numerous commercial SPE resins. High-speed automated SPE is readily accomplished by taking advantage of commercial laboratory robot systems. The present review summarizes and discusses advancements made in the use of different SPE resins and molecule tagging techniques for optimization of ion-exchange, reversed-phase, normal-phase and fluorous-phase SPE in combinatorial chemistry. (C) 2000 Elsevier Science BN. All rights reserved.

引用

页码：305 / 319

页数：15

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