Evolution of hepatitis C virus in blood donors and their respective recipients

被引：14

作者：

Cantaloube, JF ^{[1
]}

Biagini, P ^{[1
]}

Attoui, H ^{[1
]}

Gallian, P ^{[1
]}

de Micco, P ^{[1
]}

de Lamballerie, X ^{[1
]}

机构：

[1] Univ Mediterranee, Fac Med, Etablissement Francais Sang Aples Mediterranee, Unite Virus Emergents, F-13005 Marseille, France

来源：

JOURNAL OF GENERAL VIROLOGY | 2003年 / 84卷

关键词：

D O I：

10.1099/vir.0.18642-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This paper describes the study of hepatitis C virus (HCV) evolution in the largest cohort of HCV-infected blood donors (BDs)/blood recipients (BRs) reported to date (25 pairs). A molecular analysis of partial sequences in the Ell (envelope) and NS5-B (polymerase) genes was performed. Phylogenetic reconstruction showed that the evolution of dominant strains was qualitatively and quantitatively different in BDs and BRs. The evolutionary rate was significantly higher in BRs, in which, in addition, most substitutions observed were antonymous. These findings corroborate the hypothesis that a large part of virus evolution - which was evaluated to be equivalent to similar to20 years of chronic evolution - is acquired during the early phase of infection. These findings should be taken into account for the modelling of the long-term evolution of HCV and their possible contribution to improve our understanding of HCV natural history is discussed.

引用

页码：441 / 446

页数：6

共 12 条

[1] Evolutionary rate and genetic drift of hepatitis C virus are not correlated with the host immune response: Studies of infected donor-recipient clusters [J].