Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression

被引：97

作者：

Chan, Chia-Hsin ^{[1
]}

Lee, Szu-Wei ^{[1
,2
]}

Wang, Jing ^{[1
]}

Lin, Hui-Kuan ^{[1
,2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[2] Univ Texas Grad Sch Biomed Sci Houston, Houston, TX USA

来源：

THESCIENTIFICWORLDJOURNAL | 2010年 / 10卷

关键词：

Skp2; Akt; p27; SCF complex; phosphorylation; neddylation; cell migration; cancer; F-BOX PROTEIN; SCFSKP2 UBIQUITIN LIGASE; PHOSPHORYLATION-DEPENDENT PROTEOLYSIS; PROSTATE INTRAEPITHELIAL NEOPLASIA; KINASE INHIBITOR P27(KIP1); CELL-CYCLE; MEDIATED PROTEOLYSIS; DEGRADATION; P27; COMPLEX;

D O I：

10.1100/tsw.2010.89

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box protein Skp2. Skp2 forms a SCF complex with Skp1, Cul-1, and Rbx1 to constitute E3 ligase through its F-box domain. Skp2 protein levels are regulated during the cell cycle, and recent studies reveal that Skp2 stability, subcellular localization, and activity are regulated by its phosphorylation. Overexpression of Skp2 is associated with a variety of human cancers, indicating that Skp2 may contribute to the development of human cancers. The notion is supported by various genetic mouse models that demonstrate an oncogenic activity of Skp2 and its requirement in cancer progression, suggesting that Skp2 may be a novel and attractive therapeutic target for cancers.

引用

页码：1001 / 1015

页数：15

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