Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as Low-penetrance Alleles in German and Italian Familial Breast Cancer Cases

被引：138

作者：

Catucci, Irene ^{[1
,2
]}

Yang, Rongxi ^{[3
,4
]}

Verderio, Paolo ^{[5
]}

Pizzamiglio, Sara ^{[5
]}

Heesen, Ludwig ^{[3
,4
]}

Hemminki, Kari ^{[6
,7
]}

Sutter, Christian ^{[8
]}

Wappenschmidt, Barbara ^{[9
]}

Dick, Michelle ^{[3
]}

Arnold, Norbert ^{[10
]}

Bugert, Peter ^{[11
]}

Niederacher, Dieter ^{[12
]}

Meindl, Alfons ^{[13
]}

Schmutzler, Rita K. ^{[9
]}

Bartram, Claus C. ^{[8
]}

Ficarazzi, Filomena ^{[1
]}

Tizzoni, Laura ^{[1
]}

Zaffaroni, Daniela ^{[14
]}

Manoukian, Siranoush ^{[14
]}

Barile, Monica ^{[15
]}

Pierotti, Marco A. ^{[16
]}

Radice, Paolo ^{[1
,2
]}

Burwinkel, Barbara ^{[3
,4
]}

Peterlongo, Paolo ^{[1
,2
]}

机构：

[1] Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy

[2] Fdn IRCCS Ist Nazl Tumori, Dept Expt Oncol & Mol Med, Unit Genet Susceptibil Canc, Milan, Italy

[3] Univ Heidelberg, Dept Gynecol & Obstet, Div Mol Biol Breast Canc, D-69115 Heidelberg, Germany

[4] German Canc Res Ctr, Helmholtz Univ Grp Mol Epidemiol, D-69120 Heidelberg, Germany

[5] Fdn IRCCS Ist Nazl Tumori, Unit Med Stat & Biometry, Milan, Italy

[6] German Canc Res Ctr, Div Mol Genet Epidemiol, D-69120 Heidelberg, Germany

[7] Clin Res Ctr, Malmo, Sweden

[8] Univ Heidelberg, Inst Human Genet, D-69120 Heidelberg, Germany

[9] Univ Cologne, Ctr Clin, Dept Obstet & Gynaecol, Div Mol Gynecooncol, D-50931 Cologne, Germany

[10] Univ Hosp Schleswig Holstein, Dept Obstet & Gynaecol, Div Oncol, D-24105 Kiel, Germany

[11] Univ Heidelberg, Med Fac Mannheim, Red Cross Blood Serv Baden Wurttemberg Hessen, Inst Transfus Med & Immunol, D-68167 Mannheim, Germany

[12] Univ Dusseldorf, Ctr Clin, Dept Obstet & Gynaecol, Div Mol Genet, D-40225 Dusseldorf, Germany

[13] Tech Univ Munich, Klinikum Rechts Isar, Dept Gynecol & Obstet, D-81675 Munich, Germany

[14] Fdn IRCCS Ist Nazl Tumori, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy

[15] Ist Europeo Oncol, Div Canc Prevent & Genet, Milan, Italy

[16] Fdn IRCCS Ist Nazl Tumori, Sci Direct, Milan, Italy

来源：

HUMAN MUTATION | 2010年 / 31卷 / 01期

关键词：

genetic susceptibility; breast cancer risk; miRNA; rs11614913; rs3746444; rs2910164; FUNCTIONAL POLYMORPHISM; ULTRACONSERVED ELEMENTS; RISK; CARCINOMA; VARIANT; GENE;

D O I：

10.1002/humu.21141

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Recently, the SNPs rs11614913 in hsa-mir-196a2 and rs3746444 in hsa-mir-499 were reported to be associated with increased breast cancer risk, and the SNP rs2910164 in hsa-mir-146a was shown to have an effect on age of breast cancer diagnosis. In order to further investigate the effect of these SNPs, we genotyped a total of 1894 breast cancer cases negative for disease-causing mutations or unclassified variants in BRCA1 and BRCA2, and 2760 controls from Germany and Italy. We compared the genotype and allele frequencies of rs2910164, rs11614913 and rs3746444 in cases versus controls of the German and Italian series, and of the two series combined; we also investigated the effect of the three SNPs on age at breast cancer diagnosis. None of the performed analyses showed statistically significant results. In conclusion, our data suggested lack of association between SNPs rs2910164, rs11614913 and rs3746444 and breast cancer risk, or age at breast cancer onset. (C) 2009 Wiley-Liss, Inc.

引用

页码：E1052 / E1057

页数：6

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