Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues

被引：215

作者：

Besnard, V

Wert, SE

Hull, WM

Whitsett, JA ^{[2
]}

机构：

[1] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, Div Pulm Biol, Cincinnati, OH 45221 USA

[2] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, Div Neonatol, Cincinnati, OH 45221 USA

来源：

GENE EXPRESSION PATTERNS | 2004年 / 5卷 / 02期

关键词：

tissue distribution; morphogenesis; forkhead box family; transcription factor;

D O I：

10.1016/j.modgep.2004.08.006

中图分类号：

Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Members of the Forkhead box (Fox) transcription factors family Foxa1 (Hnf-3alpha), Foxa2 (Hnf-3beta) are known to influence gene expression in endodermally derived tissues including lung, liver, pancreas, stomach, and intestine. In the present study, we have generated highly specific antibodies for Foxa1 and Foxa2 and determined their expression patterns in the developing and adult mouse. Foxa1 and Foxa2 were detected in the nuclei of tissues derived from both foregut and hindgut endoderm (liver, lung, pancreas, stomach, intestine, prostate and bladder). Foxa2 and Foxa1 were also detected in organs deriving from ectodermal (several brain structures and olfactory epithelium) and mesodermal origins (kidney, vagina and uterus, seminal and coagulating glands) during development. Colocalization and distinct sites of expression of Foxa1 and Foxa2 indicate unique as well as overlapping roles of Foxa1 or Foxa2 during morphogenesis and in the function of different adult organs. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：193 / 208

页数：16

共 33 条

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ECTOPIC NEURAL EXPRESSION OF A FLOOR PLATE MARKER IN FROG EMBRYOS INJECTED WITH THE MIDLINE TRANSCRIPTION FACTOR PINTALLAVIS [J].