Further evidence for direct pro-resorptive actions of FSH

被引：54

作者：

Sun, Li ^{[1
]}

Zhang, Zhiyuan ^{[1
]}

Zhu, Ling-Ling ^{[1
]}

Peng, Yuanzhen ^{[1
]}

Liu, Xuan ^{[1
]}

Li, Jianhua ^{[1
]}

Agrawal, Manasi ^{[1
]}

Robinson, Lisa J. ^{[2
,3
]}

Iqbal, Jameel ^{[1
]}

Blair, Harry C. ^{[2
,3
]}

Zaidi, Mone ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Mt Sinai Bone Program, New York, NY 10029 USA

[2] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15243 USA

[3] Pittsburgh VA Med Ctr, Pittsburgh, PA 15243 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 394卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Osteoporosis; Osteoclast; FSH; Gonadotropin; Bone loss; FOLLICLE-STIMULATING-HORMONE; BONE-MINERAL DENSITY; POSTMENOPAUSAL OSTEOPOROSIS; MENOPAUSAL TRANSITION; HOMEOSTASIS; ESTROGEN; WOMEN; TSH; AGE;

D O I：

10.1016/j.bbrc.2010.02.113

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We confirm that FSH stimulates osteoclast formation, function and survival to enhance bone resorption. It does so via the activation of a pertussis toxin-sensitive G(i)-coupled FSH receptor that we and others have identified on murine and human osteoclast precursors and mature osteoclasts. FSH additionally enhances the production of several osteoclastogenic cytokines, importantly TNF alpha, likely within the bone marrow microenvironment, to augment its pro-resorptive action. FSH levels in humans rise before estrogen falls, and this hormonal change coincides with the most rapid rates of bone loss. On the basis of accumulating evidence, we reaffirm that FSH contributes to the rapid pen-menopausal and early post-menopausal bone loss, which might thus be amenable to FSH blockade. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：6 / 11

页数：6

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