In rat hippocampal slices, NMDA receptor-mediated EPSPs are more sensitive to hypoxia than AMPA receptor-mediated EPSPs

被引：4

作者：

Nader, R ^{[1
]}

Forghani, R ^{[1
]}

Krnjevic, K ^{[1
]}

机构：

[1] McGill Univ, Anaesthesia Res Dept, Montreal, PQ H3G 1Y6, Canada

来源：

NEUROSCIENCE LETTERS | 1998年 / 245卷 / 03期

基金：

英国医学研究理事会;

关键词：

rat hippocampal slices; CA1 field potentials; glutamate receptors;

D O I：

10.1016/S0304-3940(98)00190-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In slices kept at 33 degrees C, N-methyl-D-aspartate (NMDA) receptor- and (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole acid (AMPA) receptor-mediated field excitatory post-synaptic potentials (EPSPs) were pharmacologically isolated in CA1. Both types of EPSPs were reversibly blocked by 3 min of hypoxia (95% N-2/5% CO2); but NMDA receptor-mediated EPSPs were consistently blocked earlier and recovered later than AMPA receptor-mediated EPSPs, recorded in the same slice. This difference may be due to inactivation of NMDA receptors by hypoxia-induced acidity and/or rise in internal [Ca2+]. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：135 / 138

页数：4

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