Clonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae in Neonates

被引：40

作者：

Yin, Dandan ^{[1
]}

Dong, Dong ^{[2
,3
]}

Li, Ke ^{[4
]}

Zhang, Lei ^{[1
]}

Liang, Jianliang ^{[1
]}

Yang, Yang ^{[2
]}

Wu, Nana ^{[1
]}

Bao, Yiyan ^{[1
]}

Wang, Chuanqing ^{[1
]}

Hu, Fupin ^{[2
,3
]}

机构：

[1] Fudan Univ, Childrens Hosp, Dept Nosocomial Infect Control, Clin Microbiol Lab, Shanghai, Peoples R China

[2] Fudan Univ, Inst Antibiot, Huashan Hosp, Shanghai, Peoples R China

[3] Minist Hlth, Key Lab Clin Pharmacol Antibiot, Shanghai, Peoples R China

[4] Tongji Univ, Shanghai Peoples Hosp 10, Dept Lab Med, Shanghai, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Klebsiella pneumoniae; OXA-232; ST15; clonal dissemination; neonates; BETA-LACTAMASE; OXA-48-LIKE CARBAPENEMASES; MULTIPLEX PCR; ENTEROBACTERIACEAE; GENES; NDM-1;

D O I：

10.1128/AAC.00385-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Five OXA-232 carbapenemase-producing Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15 (ST15), were isolated from neonates and coproduced blaCTX-M-15 and bla(SHV-1) genes. All isolates were resistant to ertapenem (MICs of > 32 mu g/ml) and meropenem (MICs of 4 to 8 mu g/ml) and susceptible or intermediate to imipenem (MICs of 1 to 2 mu g/ml). The bla(OXA-232) gene was located on a ColE-type transformable plasmid of 6,141 bp. To the best of our knowledge, this is the first report of OXA-232 carbapenemase among clinical isolates in China.

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