Syntheses of 5-and 6-[2,3]-dihydrobenzofuran β-amino acids

被引：20

作者：

Coleman, PJ ^{[1
]}

Hutchinson, JH

Hunt, CA

Lu, P

Delaporte, E

Rushmore, T

机构：

[1] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA

[2] Merck Res Labs, Dept Drug Metab, W Point, PA 19486 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(00)00965-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient stereoselective syntheses of 5- and 6-[2,3]-dihydrobenzofuran beta-amino acids are described. These 3-aryl beta-amino acids are aspartic acid mimetics that are structurally related to known benzodioxole systems. In many cases, the benzodioxole can inhibit and induce cytochrome P-450; neither of these dihydrobenzofuran beta-amino esters is a potent inhibitor of several human P-450 enzymes. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：5803 / 5806

页数：4

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