Renal Function in Infants with Sickle Cell Anemia: Baseline Data from the BABY HUG Trial

被引：94

作者：

Ware, Russell E. ^{[1
]}

Rees, Renee C. ^{[2
]}

Sarnaik, Sharada A. ^{[4
]}

Iyer, Rathi V. ^{[5
]}

Alvarez, Ofelia A. ^{[6
]}

Casella, James F. ^{[3
]}

Shulkin, Barry L.

Shalaby-Rana, Eglal ^{[1
,7
]}

Strife, C. Frederic ^{[8
]}

Miller, John H. ^{[9
]}

Lane, Peter A. ^{[10
]}

Wang, Winfred C. ^{[1
]}

Miller, Scott T. ^{[11
]}

机构：

[1] St Jude Childrens Res Hosp, Memphis, TN 38105 USA

[2] Clin Trials & Surveys Corp, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[4] Childrens Hosp Michigan, Detroit, MI 48201 USA

[5] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA

[6] Univ Miami, Sch Med, Miami, FL USA

[7] Childrens Natl Med Ctr, Washington, DC 20010 USA

[8] Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH USA

[9] Harbor UCLA Med Ctr, Torrance, CA 90509 USA

[10] Emory Univ, Sch Med, Atlanta, GA USA

[11] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA

来源：

JOURNAL OF PEDIATRICS | 2010年 / 156卷 / 01期

关键词：

GLOMERULAR-FILTRATION-RATE; SERUM CYSTATIN C; TC-99M DTPA; CHILDREN; DISEASE; CLEARANCE; ABNORMALITIES; PREVALENCE; CREATININE; MARKERS;

D O I：

10.1016/j.jpeds.2009.06.060

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objectives To examine the feasibility and accuracy of glomerular filtration rate (GFR) measurements in infants with sickle cell anemia (SCA). Study design The NHLBI/NICHD-sponsored Phase III randomized double-blinded placebo-controlled trial (BABY HUG) tests the hypothesis that hydroxyurea can prevent chronic organ damage in SCA. GFR elevation is a coprimary endpoint, measured quantitatively by technetium 99m-labeled diethylenetriaminepentaacetic acid (DTPA) plasma clearance and estimated by the Schwartz equation with height and creatinine. Results Baseline DTPA GFR measurement was attempted in 191 infants; 176 of 184 completed studies (96%) were interpretable. Average age (mean +/- 1SD) was 13.7 +/- 2.6 months. Average DTPA GFR was 125.2 +/- 34.4 (range 40.2-300.9, normal 91.5 +/- 17.8 mL/min/1.73m(2)), while Schwartz estimates were higher at 184.4 +/- 55.5 mL/min/1.73m(2). DTPA GFR was correlated with Schwartz GFR (r(2) = 0.0658, P = .0012); also with age, weight, height, and kidney volume (all P < .002); but not with hemoglobin, HbF, white blood cell count, reticulocytes, medical events, or splenic function. Conclusions Quantitative GFR measurement is feasible but variable among infants with SCA. Schwartz GFR estimates are not highly correlated with quantitative DTPA GFR values. Baseline GFR measurements suggest that renal dysfunction in SCA, evidenced by glomerular hyperfiltration, begins during infancy. (J Pediatr 2010; 156: 66-70).

引用

页码：66 / U104

页数：6

共 32 条

[1] RENAL ABNORMALITIES IN SICKLE-CELL DISEASE [J].