A broadband ADEQUATE pulse sequence using chirp pulses

Recently, we have introduced the ADEQUATE pulse sequence as a sensitive method to observe C-13, C-13 correlations in natural products. This kind of experiment suffers from offset-dependent effects of the 180degrees (C-13) pulses. Here we describe an application of smoothed chirp pulses in the ADEQUATE pulse sequence which allows C-13,C-13 correlations to be run without any offset dependences. This experiment is called chirp ADEQUATE and was applied to delta-valerolactone and cholesteryl acetate. This modification will allow a general application of the ADEQUATE pulse sequence. Copyright (C) 2002 John Wiley Sons, Ltd.