5-HT1Dβ receptor mediates the supersensitivity of isolated coronary artery to serotonin in variant angina

被引：24

作者：

Ishida, T ^{[1
]}

Hirata, K ^{[1
]}

Sakoda, T ^{[1
]}

Kanazawa, K ^{[1
]}

Kawashima, S ^{[1
]}

Akita, H ^{[1
]}

Yokoyama, M ^{[1
]}

机构：

[1] Kobe Univ, Sch Med, Dept Internal Med 1, Chuo Ku, Kobe, Hyogo 650, Japan

来源：

CHEST | 1998年 / 113卷 / 01期

关键词：

coronary artery; coronary spasm; ergonovine; 5-HT1D beta receptor; serotonin; sumatriptan; variant angina;

D O I：

10.1378/chest.113.1.243

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Although serotonin (5-hydroxytryptamine; 5-HT) is used for provocation of coronary spasm, 5-HT receptor subtypes in spastic coronary arteries remain undetermined. We demonstrated the supersensitivity of isolated coronary artery to ergonovine, 5-HT, and sumatriptan, a 5-HT1D receptor agonist, in a patient with variant angina. Furthermore, we detected gene expression of 5-HT1D beta and 5-HT2A receptors in spastic coronary artery using RNase protection assay. These findings suggest that the leftward shift of the dose-response curve for 5-HT, which plays an important role in the pathogenesis of coronary spasm, is mediated by activation of 5-HT1D beta receptor.

引用

页码：243 / 244

页数：2

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