Immunobiology of Toll-like receptors in allergic disease

被引：47

作者：

Bauer, Stefan

Hangel, Doris

Yu, Philipp

机构：

[1] Univ Marburg, Inst Immunol, BMFZ, D-35043 Marburg, Germany

[2] Tech Univ Munich, Inst Med Mikrobiol Immunol & Hyg, D-81675 Munich, Germany

来源：

IMMUNOBIOLOGY | 2007年 / 212卷 / 06期

关键词：

Toll-like receptors; allergy;

D O I：

10.1016/j.imbio.2007.03.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allergic diseases prevalence rates have increased dramatically over the last 50 years in developed countries and one explanation might be that modern practices in public health lead to a decreased exposure towards pathogens resulting in a misguided immune response. Recently, it has become evident that immune responses against pathogens are initiated by Toll-like receptors (TLRs) that recognize a variety of structures derived from viruses, bacteria, fungi or protozoa. In this review we will discuss TLR ligands, TLR signaling in regard to Th1 and Th2 immune responses, their involvement in the development and their therapeutic potential in treatment of allergic disease. (C) 2007 Elsevier GmbH. All rights reserved.

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收藏

页码：521 / 533

页数：13

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