TNFAIP8 overexpression is associated with lymph node metastasis and poor prognosis in intestinal-type gastric adenocarcinoma

被引：71

作者：

Yang, Ming ^{[1
]}

Zhao, Qi ^{[1
]}

Wang, Xiaoxia ^{[2
]}

Liu, Tianbo ^{[3
]}

Yao, Guodong ^{[4
]}

Lou, Changjie ^{[1
]}

Zhang, Yanqiao ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Tumour Hosp, Dept Gastrointestinal Med Oncol, Harbin, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 2, Dept Emergency, Harbin, Heilongjiang, Peoples R China

[3] Harbin Med Univ, Affiliated Tumour Hosp, Dept Gynecol, Harbin, Heilongjiang, Peoples R China

[4] Harbin Med Univ, Affiliated Tumour Hosp, Dept Pathol, Harbin, Heilongjiang, Peoples R China

来源：

HISTOPATHOLOGY | 2014年 / 65卷 / 04期

基金：

中国国家自然科学基金;

关键词：

gastric adenocarcinoma; immunohistochemistry; prognosis; TNFAIP8; HELICOBACTER-PYLORI; CANCER; SCC-S2; IDENTIFICATION; EPIDEMIOLOGY; CARCINOMA; RADIATION; DIFFUSE;

D O I：

10.1111/his.12413

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

AimsTumour necrosis factor alpha-induced protein 8 (TNFAIP8) is implicated in the progression of several human malignancies, but its role in gastric adenocarcinoma is unknown. TNFAIP8 expression and its correlation with clinical significance in gastric adenocarcinoma are evaluated in this study. Methods and resultsThe expression of TNFAIP8 was determined in primary gastric adenocarcinoma tissues using immunohistochemistry (IHC) and Western blotting analysis. TNFAIP8 expression was higher in gastric adenocarcinoma tissues. Elevated expression of TNFAIP8 in gastric adenocarcinoma was associated significantly with depth of invasion (P=0.024), lymph node metastasis (P=0.038) and Lauren classification (P=0.048). Patients with tumours showing high TNFAIP8 expression had a significantly poorer overall survival (OS) and disease-free survival (DFS) than those with low TNFAIP8 expression in intestinal-type gastric adenocarcinoma (IGA) (P=0.001 for both). In the multivariate Cox analysis, TNFAIP8 expression was an independent prognostic marker for OS and DFS in IGA with P-values of 0.006 and 0.007, respectively. ConclusionsOur data suggest that TNFAIP8 overexpression may contribute to lymph node metastasis and poor prognosis in IGA.

引用

页码：517 / 526

页数：10

共 22 条

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