Cholestatic Liver Disease: Current Treatment Strategies and New Therapeutic Agents

被引:113
作者
Hasegawa, Sho [1 ]
Yoneda, Masato [1 ]
Kurita, Yusuke [1 ]
Nogami, Asako [1 ]
Honda, Yasushi [1 ]
Hosono, Kunihiro [1 ]
Nakajima, Atsushi [1 ]
机构
[1] Yokohama City Univ, Sch Med, Grad Sch Med, Dept Gastroenterol & Hepatol,Kanazawa Ku, 3-9 Fuku Ura, Yokohama, Kanagawa 2360004, Japan
关键词
PRIMARY SCLEROSING CHOLANGITIS; PRIMARY BILIARY-CIRRHOSIS; INFLAMMATORY-BOWEL-DISEASE; PLACEBO-CONTROLLED TRIAL; URSODEOXYCHOLIC ACID; AUTOIMMUNE HEPATITIS; NATURAL-HISTORY; DOUBLE-BLIND; INADEQUATE RESPONSE; OBETICHOLIC ACID;
D O I
10.1007/s40265-021-01545-7
中图分类号
R9 [药学];
学科分类号
100702 [药剂学];
摘要
Cholestatic liver disease is a disease that causes liver damage and fibrosis owing to bile stasis. It is represented by primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), but the pathophysiological pathways that cause bile stasis in both diseases are different. The pathogenesis of the disease is still unclear, although autoimmune mechanisms have been postulated and partially elucidated. Although the disease may progress slowly with only mild liver dysfunction, it may progress to liver cirrhosis or liver failure, which require liver transplantation. As a medical treatment, ursodeoxycholic acid is widely used for PBC and has proved to be very effective against disease progression in cases of PBC. On the other hand, its efficacy is limited in cases of PSC, and the research and development of various drugs are underway. Furthermore, the clinical course of both diseases is quite variable, making the design of clinical trials fairly difficult. In this review, we present the general natural history of PBC and PSC, and provide information on the latest drug therapies currently available and those that are under investigation.
引用
收藏
页码:1181 / 1192
页数:12
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