TrkA is necessary for the normal development of the murine thymus

被引：40

作者：

García-Suárez, O

Germanà, A

Hannestad, J

Ciriaco, E

Laurà, R

Naves, J

Esteban, I

Silos-Santiago, I

Vega, JA

机构：

[1] Univ Oviedo, Fac Med, Dept Morfol & Biol Celular, E-33006 Oviedo, Spain

[2] Univ Messina, Fac Med Vet, Ist Anat Anim Domest, I-98123 Messina, Italy

[3] Millennium Pharmaceut Inc, Dept Neurobiol, Cambridge, MA 02139 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 108卷 / 1-2期

关键词：

thymus; development; TrkA; neurotrophins; mice;

D O I：

10.1016/S0165-5728(00)00251-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nerve growth factor (NGF) and its signal-transducing receptor TrkA are expressed in the thymus. However, their possible role during thymic organogenesis is unknown. Here we analyze the thymus of trkA-kinase deficient 2-week-old mice. trkA-kinase +/+ and +/- mice had a normal thymus, whereas the thymus of trkA-kinase -/- mice showed lack of delimitation between the cortex and medulla, lower thymocyte density, and the presence of epithelial cell islands and numerous cysts lined with endodermal epithelium. The present results indicate that TrkA is necessary for the normal development of the thymus, and that its absence causes an arrest in the differentiation of endodermal epithelial cells. Whether this lack of differentiation has functional implication has yet to be determined. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：11 / 21

页数：11

共 41 条

[1] THE IMMUNOMODULATORY EFFECT OF NERVE GROWTH-FACTOR [J].