The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

被引：827

作者：

Borner, C ^{[1
]}

机构：

[1] Univ Freiburg, Inst Mol Med & Cell Res, Freiburg, Germany

来源：

MOLECULAR IMMUNOLOGY | 2003年 / 39卷 / 11期

关键词：

apoptosis; Bcl-2; bax; BH3-only; mitochondria; caspases; caspase-independent; lymphocyte survival;

D O I：

10.1016/S0161-5890(02)00252-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Members of the Bcl-2 family are crucial integrators of survival and death signals in higher eukaryotes. Although recent studies have provided novel and quite unexpected insights into the mechanisms by which these proteins might issue life permits or death sentences in cells, we are still on the way to fully understand their modes of action. This review provides a snapshot on where we are on this journey and how we may exploit our knowledge on this family of proteins to unveil the mysteries of immune regulation. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：615 / 647

页数：33

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