Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort (Hypericum perforatum L.)

被引：32

作者：

Breyer, Anja

Elstner, Matthias

Gillessen, Thomas

Weiser, Dieter

Elstner, Erich ^{[1
]}

机构：

[1] Tech Univ Munich, Lab Appl Biochem, Inst Phytopathol, D-8000 Munich, Germany

[2] Univ Munich, Dept Neurol, D-8000 Munich, Germany

[3] German Armed Forces Med Acad, Inst Pharmacol & Toxicol, Munich, Germany

[4] Steigerwald Pharma GmbH, Darmstadt, Germany

来源：

PHYTOMEDICINE | 2007年 / 14卷 / 04期

关键词：

Hypericum flavonoids; antioxidants; reactive oxygen; glutamate-induced cell death in neuronal HT22 cells; cytoprotective effects;

D O I：

10.1016/j.phymed.2007.02.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported. (c) 2007 Elsevier GmbH. All rights reserved.

引用

页码：250 / 255

页数：6

共 31 条

[1]

[Anonymous], THESIS

[2]

BANNAI S, 1986, J BIOL CHEM, V261, P2256

[3] TRANSPORT OF CYSTINE AND CYSTEINE AND CELL-GROWTH IN CULTURED HUMAN-DIPLOID FIBROBLASTS - EFFECT OF GLUTAMATE AND HOMOCYSTEATE [J].