Accelerated fluid bed drying using NIR monitoring and phenomenological modeling

被引：36

作者：

Morris, KR ^{[1
]}

Stowell, JG ^{[1
]}

Byrn, SR ^{[1
]}

Placette, AW ^{[1
]}

Davis, TD ^{[1
]}

Peck, GE ^{[1
]}

机构：

[1] Purdue Univ, Sch Pharm & Pharmacal Sci, Dept Ind & Phys Pharm, W Lafayette, IN 47907 USA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2000年 / 26卷 / 09期

关键词：

acetaminophen; drying; fluid bed; granulation; ibuprofen; near infrared; NIR;

D O I：

10.1081/DDC-100101326

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A "fast-drying" method to accelerate the fluid bed drying process is presented. It relies on concepts of heat and mass transfer with real-time near-infrared (NIR) monitoring of moisture. Triplicate trials show that fast drying can reduce granulation drying time by half over single-temperature cycles. The product is equivalent in every way tested to material made using a conventional cycle even though the inlet temperature throughout the constant-rate stage was higher than the melting point of the compound Tablets made from the fast-dried granulation exhibit equivalent physical characteristics to tablets made from granulations dried at a single, lower temperature.

引用

页码：985 / 988

页数：4