Treadmill running and targeted tibial loading differentially improve bone mass in mice

被引:19
作者
Berman, Alycia G. [1 ]
Hinton, Madicyn J. [2 ]
Wallace, Joseph M. [2 ]
机构
[1] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA
[2] Indiana Univ Purdue Univ, Dept Biomed Engn, Indianapolis, IN 46202 USA
关键词
Exercise; Tibia; Mechanical; CT; Trabecular; Cortical; CORTICAL BONE; CANCELLOUS BONE; FUNCTIONAL ADAPTATION; EXERCISE; COMPRESSION; INCREASES; STRAIN; STRENGTH; C57BL/6; MODEL;
D O I
10.1016/j.bonr.2019.100195
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Treadmill running and tibial loading are two common modalities used to assess the role of mechanical stimulation on the skeleton preclinically. The primary advantage of treadmill running is its physiological relevance. However, the applied load is complex and multiaxial, with observed results influenced by cardiovascular and musculoskeletal effects. In contrast, with tibial loading, a direct uniaxial load is applied to a single bone, providing the advantage of greater control but with less physiological relevance. Despite the importance and widespread use of both modalities, direct comparisons are lacking. In this study, we compared effects of targeted tibial loading, treadmill running, and their combination on cancellous and cortical architecture in a murine model. We show that tibial loading and treadmill running differentially improve bone mass, with tibial loading resulting in thicker trabeculae and increased cortical mass, and exercise resulting in greater number of trabeculae and no cortical mass-based effects. Combination of the modalities resulted in an additive response. These data suggest that tibial loading and exercise may improve mass differentially.
引用
收藏
页数:6
相关论文
共 35 条
[1]
Effect of in vivo loading on bone composition varies with animal age [J].
Aido, Marta ;
Kerschnitzki, Michael ;
Hoerth, Rebecca ;
Checa, Sara ;
Spevak, Lyudmila ;
Boskey, Adele L. ;
Fratzl, Peter ;
Duda, Georg N. ;
Wagermaier, Wolfgang ;
Willie, Bettina M. .
EXPERIMENTAL GERONTOLOGY, 2015, 63 :48-58
[2]
Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone [J].
Bergstrom, I. ;
Kerns, J. G. ;
Tornqvist, A. E. ;
Perdikouri, C. ;
Mathavan, N. ;
Koskela, A. ;
Henriksson, H. B. ;
Tuukkanen, J. ;
Andersson, G. ;
Isaksson, H. ;
Goodship, A. E. ;
Windahl, S. H. .
OSTEOPOROSIS INTERNATIONAL, 2017, 28 (03) :1121-1131
[3]
Structural and Mechanical Improvements to Bone Are Strain Dependent with Axial Compression of the Tibia in Female C57BL/6 Mice [J].
Berman, Alycia G. ;
Clauser, Creasy A. ;
Wunderlin, Caitlin ;
Hammond, Max A. ;
Wallace, Joseph M. .
PLOS ONE, 2015, 10 (06)
[4]
Non-invasive axial loading of mouse tibiae increases cortical bone fori-nation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element [J].
De Souza, RL ;
Matsuura, M ;
Eckstein, F ;
Rawlinson, SCF ;
Lanyon, LE ;
Pitsillides, AA .
BONE, 2005, 37 (06) :810-818
[5]
Gardinier Joseph D, 2018, Bone Rep, V8, P29, DOI 10.1016/j.bonr.2018.01.003
[6]
Treadmill Exercise Improves Fracture Toughness and Indentation Modulus without Altering the Nanoscale Morphology of Collagen in Mice [J].
Hammond, Max A. ;
Laine, Tyler J. ;
Berman, Alycia G. ;
Wallace, Joseph M. .
PLOS ONE, 2016, 11 (09)
[7]
Exercise prevents beta-aminopropionitrile-induced morphological changes to type I collagen in murine bone [J].
Hammond, Max A. ;
Wallace, Joseph M. .
BONEKEY REPORTS, 2015, 4
[8]
Swim-trained rats have greater bone mass, density, strength, and dynamics [J].
Hart, KJ ;
Shaw, JM ;
Vajda, E ;
Hegsted, M ;
Miller, SC .
JOURNAL OF APPLIED PHYSIOLOGY, 2001, 91 (04) :1663-1668
[9]
Adaptation of Tibial Structure and Strength to Axial Compression Depends on Loading History in Both C57BL/6 and BALB/c Mice [J].
Holguin, Nilsson ;
Brodt, Michael D. ;
Sanchez, Michelle E. ;
Kotiya, Akhilesh A. ;
Silva, Matthew J. .
CALCIFIED TISSUE INTERNATIONAL, 2013, 93 (03) :211-221
[10]
Differential effect of treadmill exercise on three cancellous bone sites in the young growing rat (Publication with Expression of Concern. See vol. 128, 2019) (Publication with Expression of Concern. See vol. 162, 2022) [J].
Iwamoto, J ;
Yeh, JK ;
Aloia, JF .
BONE, 1999, 24 (03) :163-169