A signal for the caspase-1 inflammasome free of TLR

被引：32

作者：

Dinarello, Charles A. ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA

来源：

IMMUNITY | 2007年 / 26卷 / 04期

关键词：

D O I：

10.1016/j.immuni.2007.04.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Secretion of the proinflammatory cytokine IL-1 beta requires caspase-1 and Toll-like receptor (TLR) signaling. However, Kanneganti et al. (2007) find that bacteria can use pore-forming mechanisms to activate caspase-1 for the production of IL-1 beta precursor independently of TLRs.

引用

页码：383 / 385

页数：3

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