Does metformin induce ovulation in normoandrogenic anovulatory women?

被引:18
作者
Carmina, E
Lobo, RA
机构
[1] Columbia Univ, Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10032 USA
[2] Univ Palermo, Dept Clin Med, Palermo, Italy
关键词
anovulation; infertility; metformin;
D O I
10.1016/j.ajog.2004.05.030
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: This study was undertaken to evaluate the efficacy of metformin in women with anovulation who do not have evidence for hyperandrogenism and classic polycystic ovary syndrome. Study design: A randomized trial of metformin (1500 mg daily) and placebo in 24 anovulatory women was undertaken for 3 months. Assessments of changes in hormone levels and insulin sensitivity were carried out. Abnormal hormonal values were defined by levels exceeding the range in normal ovulatory controls. Results: Anovulatory women had normal androgen levels and luteinizing hormone but had higher serum insulin and lower insulin sensitivity compared with controls. Over 3 months, there were 16 ovulatory cycles with metformin and only 4 with placebo (P < .05). Success of ovulation did not correlate with changes in androgen, insulin, or insulin sensitivity parameters. Conclusion: Metformin may be useful for inducing ovulation in anovulatory women who do not have hyperandrogenism. This effect may be independent of a lowering of androgen or insulin levels. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:1580 / 1584
页数:5
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