Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic Hepatitis B virus infection

被引：70

作者：

Zoulim, F ^{[1
]}

机构：

[1] Inst Univ France, INSERM, Unit 271, F-69003 Lyon, France

来源：

ANTIVIRAL RESEARCH | 2004年 / 64卷 / 01期

关键词：

hepatitis B; viral persistence; viral resistance; viral clearance; nucleosides; nucleotides; immunopathology;

D O I：

10.1016/j.antiviral.2004.07.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic Hepatitis B virus (HBV) infections remain a major problem public health problem worldwide, as well as a therapeutic challenge for clinicians. This review focuses on the main viral and host determinants involved in HBV persistence in infected cells. The mechanism of HBV resistance to nucleoside analogs are described as well as the concept for multiple drug therapy and combination with immunostimulatory approaches. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1 / 15

页数：15

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