Avoidance and management of positive surgical margins before, during and after radical prostatectomy

被引:22
作者
Bott, SRJ [1 ]
Kirby, RS
机构
[1] Inst Urol & Nephrol, 67 Riding House St, London W1W 7EY, England
[2] Univ London St Georges Hosp, Dept Urol, London, England
关键词
prostate cancer; prostatectomy; surgical margins; prevention; treatment;
D O I
10.1038/sj.pcan.4500612
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Positive surgical margins after radical prostatectomy lead to an increased risk of progression and reduced disease free survival. Earlier detection of prostate cancer, appropriate patient selection and improved operative techniques can reduce the incidence of positive margins, though the risk can not be eliminated as preoperative staging techniques are not sufficiently sensitive. Nerve sparing and bladder neck sparing do not adversely affect margin status in appropriately selected men. Once positive margins have been diagnosed the optimal management and the timing of treatment remains controversial. Adjuvant radiotherapy or salvage radiotherapy in men with a low PSA may improve local control and PSA free survival in some individuals, a survival benefit has not yet been established.
引用
收藏
页码:252 / 263
页数:12
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