CD4+ and CD8+ T Cell Activation Are Associated with HIV DNA in Resting CD4+ T Cells

被引：88

作者：

Cockerham, Leslie R. ^{[1
]}

Siliciano, Janet D. ^{[2
]}

Sinclair, Elizabeth ^{[3
]}

O'Doherty, Una ^{[4
]}

Palmer, Sarah ^{[5
,6
,7
]}

Yukl, Steven A. ^{[8
]}

Strain, Matt C. ^{[9
]}

Chomont, Nicolas ^{[11
]}

Hecht, Frederick M. ^{[1
]}

Siliciano, Robert F. ^{[2
,12
]}

Richman, Douglas D. ^{[9
,10
]}

Deeks, Steven G. ^{[1
]}

机构：

[1] Univ Calif San Francisco, San Francisco Gen Hosp, Div HIV AIDS, San Francisco, CA 94143 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[3] Univ Calif San Francisco, Div Expt Med, San Francisco, CA 94143 USA

[4] Univ Penn, Philadelphia, PA 19104 USA

[5] Westmead Millennium Inst Med Res, Westmead, NSW, Australia

[6] Univ Sydney, Sydney, NSW 2006, Australia

[7] Karolinska Inst, Stockholm, Sweden

[8] San Francisco VA Med Ctr, San Francisco, CA USA

[9] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA

[10] Univ Calif San Diego, La Jolla, CA 92093 USA

[11] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA

[12] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA

来源：

PLOS ONE | 2014年 / 9卷 / 10期

基金：

美国国家卫生研究院;

关键词：

SUPPRESSIVE ANTIRETROVIRAL THERAPY; IMMUNE ACTIVATION; VIRAL PERSISTENCE; INFECTED PATIENTS; RESERVOIR; SIZE; REPLICATION; INTEGRATION; LYMPHOCYTES; EXPRESSION;

D O I：

10.1371/journal.pone.0110731

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4(+) and CD8(+) T cells expressing HLA-DR and the frequency of resting CD4(+) T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies.

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