Mono(6A-N-allylamino-6A-deoxy)perphenylcarbamoylated β-cyclodextrin:: synthesis and application as a chiral stationary phase for HPLC

被引：39

作者：

Lai, XH ^{[1
]}

Ng, SC ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 119260, Singapore

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 13期

关键词：

cyclodextrin; hydrosilylation; chiral stationary phases; enantioseparation;

D O I：

10.1016/S0040-4039(03)00347-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel cyclodextrin derivative: mono(6(A)-N-allylamino-6(A)-deoxy)perphenylcarbamoylated beta-cyclodextrin was synthesized. Hydrosilylation with (EtO)(3)SiH and then reaction of the reactive siloxane with pristine silica gel afforded a facile entry into a durable, structurally well-defined chiral stationary phase capable of enantioseparation of a variety of racemic drugs. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2657 / 2660

页数：4

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