PI3K in lymphocyte development, differentiation and activation

被引：657

作者：

Okkenhaug, K ^{[1
]}

Vanhaesebroeck, B

机构：

[1] Babraham Inst, Mol Immunol Programme, Cambridge CB2 4AT, England

[2] Ludwig Inst Canc Res, Cell Signalling Grp, London W1W 7BS, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nri1056

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Phosphoinositide 3-kinases (PI3Ks) regulate numerous biological processes, including cell growth, differentiation, survival, proliferation, migration and metabolism. In the immune system, impaired PI3K signalling leads to immunodeficiency, whereas unrestrained PI3K signalling contributes to autoimmunity and leukaemia. New insights into the role of PI3Ks in lymphocyte biology have been derived from gene-targeting studies, which have identified the PI3K subunits that are involved in B-cell and T-cell signalling. In particular, the catalytic subunit p110delta seems to be adapted to transmit antigen-receptor signalling in B and T cells. Additional recent work has provided new insights into the molecular interactions that lead to PI3K activation and the signalling pathways that are regulated by PI3K.

引用

收藏

页码：317 / 330

页数：14

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