Integrase illuminated

被引：20

作者：

Cherepanov, Peter ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England

来源：

EMBO REPORTS | 2010年 / 11卷 / 05期

基金：

英国医学研究理事会;

关键词：

HIV-1; INTEGRASE; STRAND TRANSFER; INHIBITORS;

D O I：

10.1038/embor.2010.58

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antiretroviral drugs to prevent integration of the HIV viral genome into chromosomes are undergoing clinical trials, yet they have been developed with an imperfect understanding of their mechanism of action. The recent crystal structure of the major viral protein integrase from a related, little‐known retrovirus, has finally provided insight into how the drugs work and, more importantly, how to improve them.

引用

页码：328 / 328

页数：1

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