Augmented immunological activities of recombinant lipopolysaccharide possessing the mannose homopolymer as the O-specific polysaccharide

被引:10
作者
Paeng, N
Kido, N
Schmidt, G
Sugiyama, T
Kato, Y
Koide, N
Yokochi, T
机构
[1] AICHI MED UNIV,DEPT MICROBIOL & IMMUNOL,NAGAKUTE,AICHI 48011,JAPAN
[2] NAGOYA UNIV,SCH INFORMAT & SCI,DEPT NAT SCI INFORMAT,NAGOYA,AICHI 46401,JAPAN
[3] FORSCHUNGSINST BORSTEL,W-2061 BORSTEL,GERMANY
关键词
D O I
10.1128/IAI.64.1.305-309.1996
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recombinant lipopolysaccharide possessing the mannose homopolymer as the O-specific polysaccharide was manufactured genetically by transforming Escherichia coli K-12 with various rfb genes capable of synthesizing the mannose homopolymer, Recombinant lipopolysaccharide exhibited levels of anticomplement activity, adjuvant activity, and regional lymph node-enlarging activity much higher than those exhibited by the original rough-type lipopolysaccharide from E. coli K-12 or lipopolysaccharide possessing the heteropolysaccharide from E. coli O111, Immunological activities of recombinant lipopolysaccharide were as strong as those of wild-type lipopolysaccharide possessing the mannose homopolymer. Characteristic activities of wild-type lipopolysaccharide possessing the mannose homopolymer were exhibited by recombinant lipopolysaccharide, The abilities of lipopolysaccharide to activate B cells polyclonally and to produce cytokines did not seem to be related to the presence of the mannose homopolymer. Therefore, it was suggested that the mannose homopolymer in the O-specific polysaccharide might exclusively enhance anticomplement activity, adjuvant activity, and regional lymph node-enlarging activity among various lipid A activities.
引用
收藏
页码:305 / 309
页数:5
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