Hemoglobin autooxidation/oxidation mechanisms and methemoglobin prevention or reduction processes in the bloodstream - Literature review and outline of autooxidation reaction

被引:87
作者
Faivre, B [1 ]
Menu, P [1 ]
Labrude, P [1 ]
Vigneron, C [1 ]
机构
[1] Univ Nancy 1, Fac Pharm, IFR Biomat W0070, Lab Hematol Physiol, F-54001 Nancy, France
来源
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 1998年 / 26卷 / 01期
关键词
D O I
10.3109/10731199809118943
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The amount of circulating methemoglobin in healthy humans is the result of a balance between methemoglobin production (from autooxidation and oxidation) and hemoglobin reduction. Hemoglobin autooxidation and oxidation are very complex and are not well understood. This article analyses the literature on hemoglobin(1) autooxidation, oxidation and reduction and sets out a sequence of reactions for the oxidation of hemoglobin and the ways in which the percentage of methemoglobin is regulated or methemoglobin production prevented. Most of the information concerns erythrocyte hemoglobin, but plasma extracellular hemoglobin (from hemolysis or hemoglobin-based blood substitutes) is also considered where possible.
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页码:17 / 26
页数:10
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