The dynamics of thrombin formation

被引:401
作者
Mann, KG [1 ]
Butenas, S [1 ]
Brummel, K [1 ]
机构
[1] Univ Vermont, Coll Med, Dept Biochem, Burlington, VT 05405 USA
关键词
coagulation; fibrinogen; aggregation; coagulation inhibitors;
D O I
10.1161/01.ATV.0000046238.23903.FC
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The central event of the hemostatic process is the generation of thrombin through the tissue factor pathway. This is a highly regulated, dynamic process in which thrombin itself plays many roles, positively and negatively its production and destruction. The hemostatic process is essential to normal physiology and is also the Achilles heel of our aging population. The inappropriate generation of thrombin may lead to vascular occlusion with the consequence of myocardial infarction, stroke, pulmonary embolism, or venous thrombosis. In this review, we summarize our present views regarding the tissue factor pathway by which thrombin is generated and the roles played by extrinsic and intrinsic factor Xa generating complexes in hemostasis and the roles of the stoichiometric and dynamic inhibitors that regulate thrombin generation.
引用
收藏
页码:17 / 25
页数:9
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