Biodefense-driven murine model of pneumonic melioidosis

被引：80

作者：

Jeddeloh, JA ^{[1
]}

Fritz, DL ^{[1
]}

Waag, DM ^{[1
]}

Hartings, JM ^{[1
]}

Andrews, GP ^{[1
]}

机构：

[1] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 01期

关键词：

D O I：

10.1128/IAI.71.1.584-587.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A whole-body mouse model of pneumonic melioidosis was established for future evaluation of biodefense vaccine candidates. The aerosol 50% lethal doses of Burkholderia pseudomallei strain 1026b for BALB/c and C57BL/6 mice and the times to death, dissemination in organs, and tissue loads after exposure of the mice to low- and high-dose aerosols are reported. In addition, rpsL mutant backgrounds were attenuated in this acute model of disease.

引用

页码：584 / 587

页数：4

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