Synthetic metallomolecules as agents for the control of DNA structure

被引：187

作者：

Richards, Adair D.

Rodger, Alison ^{[1
]}

机构：

[1] Univ Warwick, Mol Org & Assembly Cells Doctoral Training Ctr, Coventry CV4 7AL, W Midlands, England

[2] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

CHEMICAL SOCIETY REVIEWS | 2007年 / 36卷 / 03期

关键词：

D O I：

10.1039/b609495c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This tutorial review summarises B-DNA structure and metallomolecule binding modes and illustrates some DNA structures induced by molecules containing metallic cations. The effects of aquated metal ions, cobalt amines, ruthenium octahedral metal complexes, metallohelicates and platinum complexes such as cis-platin are discussed alongside the techniques of NMR, X-ray crystallography, gel electrophoresis, circular dichroism, linear dichroism and molecular dynamics. The review will be of interest to people interested in both DNA structure and roles of metallomolecules in biological systems.

引用

收藏

页码：471 / 483

页数：13

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