Cytotoxic triterpenes from the twigs of Celtis philippinensis

被引：59

作者：

Hwang, BY

Chai, HB

Kardono, LBS

Riswan, S

Farnsworth, NR

Cordell, GA

Pezzuto, JM

Kinghorn, AD ^{[1
]}

机构：

[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

[3] Indonesian Inst Sci, Res Ctr Chem, Tangerang 15310, Indonesia

[4] Indonesian Inst Sci, Biol Res Ctr, Herbarium Bogoriense, Bogor 16122, Indonesia

来源：

PHYTOCHEMISTRY | 2003年 / 62卷 / 02期

关键词：

Celtis philippinensis; Ulmaceae; twigs; triterpenoids; 3 beta-trans-sinapoyloxylup-20(29)-en-28-ol; 3 beta-trans-feruloyloxy-16 beta-hydroxylup-20(29)-ene; cytotoxicity evaluation;

D O I：

10.1016/S0031-9422(02)00520-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Two triterpene esters, 3beta-trans-sinapoyloxylup-20(29)-en-28-ol (1) and 3beta-trans-feruloyloxy-16beta-hydroxylup-20(29)-ene (2), were isolated as cytotoxic constituents from the chloroform-soluble extract of the twigs of Celtis philippinensis, along with five known triterpenes, 3beta-O-(E)-feruloylbetulin (3), 3beta-O-(E)-coumaroylbetulin (4), betulin (5), 20-epibryonolic acid (6), and ursolic acid (7). The structures of 1 and 2 were assigned from their 1 D and 2D NMR spectroscopic data. All isolates were evaluated for cytotoxicity against several human cancer cell lines. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：197 / 201

页数：5

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